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There are many causes for an underactive thyroid gland (hypothyroidism). Below are the four main causes for this condition. Autoimmune Disease: Autoimmune disease happens when the immune system produces antibodies which attack the tissues in a body. Occasionally, this process occurs in the thyroid gland which causes hypothyroidism. Radiation Therapy: Radiation therapy used to treat cancer can hurt the thyroid gland. This can lead to hypothyroidism. Thyroid Surgery: When part or all of your thyroid gland is removed, thyroid hormone production can be decreased. This can also cause hypothyroidism. Medications: Medications can also cause hypothyroidism. Medications like lithium, which are used to treat certain disorders, have been known to sometimes be the reason for hypothyroidism. There are other, but less common causes for an underactive thyroid gland. They include:
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